Publications
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Gulka S, Litke AM, Delaney KR and Chow RL. Laser-induced micro-injury of the corneal basal epithelium and imaging of resident macrophage responses in a live, whole-eye preparation. Frontiers in Immunology, 14: 1050594, 2023, doi: 10.3389/fimmu.2023.1050594
Mesa Perez M, Hamilton P, Miranda Rodriguez A, Brodie N, O’Sullivan C, Christie J, Ryan B, Chow R, Goodlett D, Nelson C, Howard P. Cytoplasmic Switch of ARS2 Isoforms Promotes Nonsense-Mediated mRNA Decay and Arsenic Sensitivity. Nucleic Acids Research. 2022
Waldner DM, Ito K, Chen LL, Nguyen L, Chow RL, Lee A, Rancourt DE, Tremblay F, Stell WK, Bech-Hansen NT. Transgenic Expression of Cacna1f Rescues Vision and Retinal Morphology in a Mouse Model of Congenital Stationary Night Blindness 2A (CSNB2A). Translational Vision Science & Technology 2020, Vol.9, 19. doi:https://doi.org/10.1167/tvst.9.11.19
Bannister AH, Bromma K, Sung W, Monica M, Cicon L, Howard P, Chow RL, Schuemann J, Chithrani DB. Modulation of nanoparticle uptake, intracellular distribution, and retention with docetaxel to enhance radiotherapy. Br J Radiol. 2020; 93(1106):20190742. doi: 10.1259/bjr.20190742.
O'Sullivan C, Nickerson PEB, Krupke O, Christie J, Chen LL, Mesa-Peres M, Zhu M, Ryan B, Chow RL, Howard PL. ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification. Biochem Cell Biol. 2020 Feb;98(1):50-60. doi: 10.1139/bcb-2018-0250
Debrulle S, Baudouin C, Hidalgo-Figueroa M, Pelosi B, Francius C, Rucchin V, Ronellenfitch K, Chow RL, Tissir F, Lee SK, Clotman F. Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development. Cell Mol Life Sci. 2019, doi: 10.1007/s00018-019-03408-7.
Litke AM, Samuelson S, Delaney KR, Sauvé Y, Chow RL. Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5824-5835
Ryan BC, Lowe K, Hanson L, Gil T, Braun L, Howard PL, Chow RL. Mapping the Pax6 3' untranslated region microRNA regulatory landscape. BMC Genomics. 2018, 19(1):820. doi: 10.1186/s12864-018-5212-x.
Yongblah K, Alford SC, Ryan BC, Chow RL, Howard PL. Protecting Pax6 3' UTR from MicroRNA-7 Partially Restores PAX6 in Islets from an Aniridia Mouse Model. Mol Ther Nucleic Acids. 2018, 13:144-153.
Good KV, Martínez de Paz A, Tyagi M, Cheema MS, Thambirajah AA, Gretzinger TL, Stefanelli G, Chow RL, Krupke O, Hendzel M, Missiaen K, Underhill A, Landsberger N, Ausió J. Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity. Epigenetics. 2017;12(11):934-944
Francius C, Hidalgo-Figueroa M, Debrulle S, Pelosi B, Rucchin V, Ronellenfitch K, Panayiotou E, Makrides N, Misra K, Harris A, Hassani H, Schakman O, Parras C, Xiang M, Malas S, Chow RL, Clotman F. Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord. Front Mol Neurosci. 2016;9:145
Ryan BC, Werner TS, Howard PL, Chow RL. (ImiRP: a computational approach to microRNA target site mutation. BMC Bioinformatics, 2016;17:190
Francius C, Hidalgo-Figueroa M, Ronellenfitch K, Panayiotou Worth E, Misra K, Parras C, Xiang M, Malas S, Chow RL, Clotman F. Identification of a novel population of V2 interneurons in the developing mouse spinal cord. Int J Dev Neurosci. 2015;47(Pt A):16.
O'Sullivan C, Christie J, Pienaar M, Gambling J, Nickerson PE, Alford SC, Chow RL, Howard PL. Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis. Mol Cell Biol. 2015;35(21):3753-67
Nickerson PEB, Ronellenfitch K, Howard PL, Delaney KR, Chow RL, Live imaging and analysis of postnatal mouse retinal development, BMC Dev Biol. 2013;10;13(1):24.
Zhu MY, Gasperowicz M, Chow RL. The expression of NOTCH2, HES1 and SOX9 during mouse retinal development. Gene Expr Patterns, 2013;13(3-4):78-83
Star EN, Zhu M, Liu H, Pashmforoush M, Sauve Y, Bruneau BG, Chow RL. Regulation of retinal bipolar cell type identity by the Iroquois homeobox gene, Irx6. Development, 2012;139(24):2644-55.
Shi Z, Jervis D, Nickerson PE, Chow RL. A requirement for the paired-like homeodomain transcription factor Vsx1 in Type 3a mouse retinal bipolar cell terminal differentiation. J Comp Neurol., 2012;520(1):117-29.
Nickerson PEB, Ronellenfitch K, McEwan J, Kim H, McInnes RR, Chow RL. A transgenic mouse line expressing Cre recombinase in undifferentiated postmitotic mouse retinal bipolar cell precursors, PLoS ONE. 2011;6(10): e27145. doi:10.1371/journal.pone.0027145
Shi Z, Trenholm S, Zhu M, Buddingh S, Awatramani G, Chow RL. Vsx1 regulates Type 7 ON bipolar cell terminal differentiation, The Journal of Neuroscience, 2011;31(37):13118-27.
Watson T, Chow RL. Absence of Vsx1 expression in the normal and damaged mouse cornea, Mol Vis., 2011;17:737-44
Nickerson PE, Myers T, Clarke DB, Chow RL. Changes in Musashi-1 subcellular localization correlate with cell cycle exit during postnatal retinal development. Exp Eye Res.. 2011;92(5):344-52
Kerschensteiner D, Liu H, Cheng CW, Demas J, Cheng SH, Hui CC, Chow RL, Wong ROL Genetic control of circuit function: Vsx1 and Irx5 transcription factors regulate contrast adaptation in the mouse retina. Journal of Neuroscience, 2008;28(10):2342-52.
Clark AM, Yun S, Veien ES, Wu YY, Chow RL, Dorsky RI, Levine EM. Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina. Brain Res. 2008;1192:99-113.
Feng L, Xie X, Joshi PS, Yang Z, Shibasaki K, Chow RL, Gan L. Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina. Development. 2006;133(24):4815-25.
Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X,
Bruneau X, Birch DG, Hui Cc, McInnes RR, Cheng CH. The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development, Developmental Biology, 2005;287(1), 48-60.
Chow RL, Volgyi B, Szilard RK, Ng D, McKerlie C, Bloomfield SA, Birch DG and McInnes RR. Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1. Proc. Nat’l Acad. Sci., 2004;101:(6), 1754–1759.
Héon E, Greenberg A, Kopp KK, Rootman D, Vincent AL, Billingsley G, Priston M, Dorval K, Chow RL, McInnes RR, Heathcote G, Westall C, Sutphin C, Semina E, Bremner R, Stone EM. VSX1: A gene for posterior polymorphous dystrophy and keratoconus. Human Molecular Genetics. 2002;11(9), 1029-1036.
Chow RL, Snow B, Novak J, Looser J, Freund C, Vidgen D, Ploder L and McInnes RR. Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells. Mechanisms of Development. 2001;109, 313-319.
Chow RL, Altmann CR, Lang RA and Hemmati-Brivanlou A. Pax6 induces ectopic eyes in a vertebrate. Development. 1999; 126, 4213-22.
Williams SC, Altmann CR, Chow RL, Hemmati-Brivanlou A, and Lang RA. A highly conserved lens transcriptional control element from the Pax-6 gene. Mechanisms of Development. 1998;73, 225-9.
Altmann CR, Chow RL, Lang RA and Hemmati-Brivanlou A. Lens induction by Pax-6 in Xenopus laevis. Developmental Biolog. 1997;185, 119-23.
Chow RL, Roux GD, Roghani M, Palmer MA, Rifkin DB, Moscatelli DA and Lang RA. FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens. Development 121, 1995;4383-93
view in Pubmed
Gulka S, Litke AM, Delaney KR and Chow RL. Laser-induced micro-injury of the corneal basal epithelium and imaging of resident macrophage responses in a live, whole-eye preparation. Frontiers in Immunology, 14: 1050594, 2023, doi: 10.3389/fimmu.2023.1050594
Mesa Perez M, Hamilton P, Miranda Rodriguez A, Brodie N, O’Sullivan C, Christie J, Ryan B, Chow R, Goodlett D, Nelson C, Howard P. Cytoplasmic Switch of ARS2 Isoforms Promotes Nonsense-Mediated mRNA Decay and Arsenic Sensitivity. Nucleic Acids Research. 2022
Waldner DM, Ito K, Chen LL, Nguyen L, Chow RL, Lee A, Rancourt DE, Tremblay F, Stell WK, Bech-Hansen NT. Transgenic Expression of Cacna1f Rescues Vision and Retinal Morphology in a Mouse Model of Congenital Stationary Night Blindness 2A (CSNB2A). Translational Vision Science & Technology 2020, Vol.9, 19. doi:https://doi.org/10.1167/tvst.9.11.19
Bannister AH, Bromma K, Sung W, Monica M, Cicon L, Howard P, Chow RL, Schuemann J, Chithrani DB. Modulation of nanoparticle uptake, intracellular distribution, and retention with docetaxel to enhance radiotherapy. Br J Radiol. 2020; 93(1106):20190742. doi: 10.1259/bjr.20190742.
O'Sullivan C, Nickerson PEB, Krupke O, Christie J, Chen LL, Mesa-Peres M, Zhu M, Ryan B, Chow RL, Howard PL. ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification. Biochem Cell Biol. 2020 Feb;98(1):50-60. doi: 10.1139/bcb-2018-0250
Debrulle S, Baudouin C, Hidalgo-Figueroa M, Pelosi B, Francius C, Rucchin V, Ronellenfitch K, Chow RL, Tissir F, Lee SK, Clotman F. Vsx1 and Chx10 paralogs sequentially secure V2 interneuron identity during spinal cord development. Cell Mol Life Sci. 2019, doi: 10.1007/s00018-019-03408-7.
Litke AM, Samuelson S, Delaney KR, Sauvé Y, Chow RL. Investigating the Pathogenicity of VSX1 Missense Mutations and Their Association With Corneal Disease. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5824-5835
Ryan BC, Lowe K, Hanson L, Gil T, Braun L, Howard PL, Chow RL. Mapping the Pax6 3' untranslated region microRNA regulatory landscape. BMC Genomics. 2018, 19(1):820. doi: 10.1186/s12864-018-5212-x.
Yongblah K, Alford SC, Ryan BC, Chow RL, Howard PL. Protecting Pax6 3' UTR from MicroRNA-7 Partially Restores PAX6 in Islets from an Aniridia Mouse Model. Mol Ther Nucleic Acids. 2018, 13:144-153.
Good KV, Martínez de Paz A, Tyagi M, Cheema MS, Thambirajah AA, Gretzinger TL, Stefanelli G, Chow RL, Krupke O, Hendzel M, Missiaen K, Underhill A, Landsberger N, Ausió J. Trichostatin A decreases the levels of MeCP2 expression and phosphorylation and increases its chromatin binding affinity. Epigenetics. 2017;12(11):934-944
Francius C, Hidalgo-Figueroa M, Debrulle S, Pelosi B, Rucchin V, Ronellenfitch K, Panayiotou E, Makrides N, Misra K, Harris A, Hassani H, Schakman O, Parras C, Xiang M, Malas S, Chow RL, Clotman F. Vsx1 Transiently Defines an Early Intermediate V2 Interneuron Precursor Compartment in the Mouse Developing Spinal Cord. Front Mol Neurosci. 2016;9:145
Ryan BC, Werner TS, Howard PL, Chow RL. (ImiRP: a computational approach to microRNA target site mutation. BMC Bioinformatics, 2016;17:190
Francius C, Hidalgo-Figueroa M, Ronellenfitch K, Panayiotou Worth E, Misra K, Parras C, Xiang M, Malas S, Chow RL, Clotman F. Identification of a novel population of V2 interneurons in the developing mouse spinal cord. Int J Dev Neurosci. 2015;47(Pt A):16.
O'Sullivan C, Christie J, Pienaar M, Gambling J, Nickerson PE, Alford SC, Chow RL, Howard PL. Mutagenesis of ARS2 Domains To Assess Possible Roles in Cell Cycle Progression and MicroRNA and Replication-Dependent Histone mRNA Biogenesis. Mol Cell Biol. 2015;35(21):3753-67
Nickerson PEB, Ronellenfitch K, Howard PL, Delaney KR, Chow RL, Live imaging and analysis of postnatal mouse retinal development, BMC Dev Biol. 2013;10;13(1):24.
Zhu MY, Gasperowicz M, Chow RL. The expression of NOTCH2, HES1 and SOX9 during mouse retinal development. Gene Expr Patterns, 2013;13(3-4):78-83
Star EN, Zhu M, Liu H, Pashmforoush M, Sauve Y, Bruneau BG, Chow RL. Regulation of retinal bipolar cell type identity by the Iroquois homeobox gene, Irx6. Development, 2012;139(24):2644-55.
Shi Z, Jervis D, Nickerson PE, Chow RL. A requirement for the paired-like homeodomain transcription factor Vsx1 in Type 3a mouse retinal bipolar cell terminal differentiation. J Comp Neurol., 2012;520(1):117-29.
Nickerson PEB, Ronellenfitch K, McEwan J, Kim H, McInnes RR, Chow RL. A transgenic mouse line expressing Cre recombinase in undifferentiated postmitotic mouse retinal bipolar cell precursors, PLoS ONE. 2011;6(10): e27145. doi:10.1371/journal.pone.0027145
Shi Z, Trenholm S, Zhu M, Buddingh S, Awatramani G, Chow RL. Vsx1 regulates Type 7 ON bipolar cell terminal differentiation, The Journal of Neuroscience, 2011;31(37):13118-27.
Watson T, Chow RL. Absence of Vsx1 expression in the normal and damaged mouse cornea, Mol Vis., 2011;17:737-44
Nickerson PE, Myers T, Clarke DB, Chow RL. Changes in Musashi-1 subcellular localization correlate with cell cycle exit during postnatal retinal development. Exp Eye Res.. 2011;92(5):344-52
Kerschensteiner D, Liu H, Cheng CW, Demas J, Cheng SH, Hui CC, Chow RL, Wong ROL Genetic control of circuit function: Vsx1 and Irx5 transcription factors regulate contrast adaptation in the mouse retina. Journal of Neuroscience, 2008;28(10):2342-52.
Clark AM, Yun S, Veien ES, Wu YY, Chow RL, Dorsky RI, Levine EM. Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina. Brain Res. 2008;1192:99-113.
Feng L, Xie X, Joshi PS, Yang Z, Shibasaki K, Chow RL, Gan L. Requirement for Bhlhb5 in the specification of amacrine and cone bipolar subtypes in mouse retina. Development. 2006;133(24):4815-25.
Cheng CW, Chow RL, Lebel M, Sakuma R, Cheung HO, Thanabalasingham V, Zhang X,
Bruneau X, Birch DG, Hui Cc, McInnes RR, Cheng CH. The Iroquois homeobox gene, Irx5, is required for retinal cone bipolar cell development, Developmental Biology, 2005;287(1), 48-60.
Chow RL, Volgyi B, Szilard RK, Ng D, McKerlie C, Bloomfield SA, Birch DG and McInnes RR. Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1. Proc. Nat’l Acad. Sci., 2004;101:(6), 1754–1759.
Héon E, Greenberg A, Kopp KK, Rootman D, Vincent AL, Billingsley G, Priston M, Dorval K, Chow RL, McInnes RR, Heathcote G, Westall C, Sutphin C, Semina E, Bremner R, Stone EM. VSX1: A gene for posterior polymorphous dystrophy and keratoconus. Human Molecular Genetics. 2002;11(9), 1029-1036.
Chow RL, Snow B, Novak J, Looser J, Freund C, Vidgen D, Ploder L and McInnes RR. Vsx1, a rapidly evolving paired-like homeobox gene expressed in cone bipolar cells. Mechanisms of Development. 2001;109, 313-319.
Chow RL, Altmann CR, Lang RA and Hemmati-Brivanlou A. Pax6 induces ectopic eyes in a vertebrate. Development. 1999; 126, 4213-22.
Williams SC, Altmann CR, Chow RL, Hemmati-Brivanlou A, and Lang RA. A highly conserved lens transcriptional control element from the Pax-6 gene. Mechanisms of Development. 1998;73, 225-9.
Altmann CR, Chow RL, Lang RA and Hemmati-Brivanlou A. Lens induction by Pax-6 in Xenopus laevis. Developmental Biolog. 1997;185, 119-23.
Chow RL, Roux GD, Roghani M, Palmer MA, Rifkin DB, Moscatelli DA and Lang RA. FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens. Development 121, 1995;4383-93